Ausgewählte Publikationen

Institut für Neuropathologie

Arbeitsgruppe Prof. Dr. Christine Stadelmann-Nessler

  • Bergner CG, van der Meer F, Winkler W, Wrzos C, Türkmen M, Valizada E, Fitzner D, Hametner S, Hartmann A, Pfeifenbring S, Stoltenburg-Didinger G, Brück W, Nessler S, Stadelmann C (2019) Microglia damage precedes major myelin destruction in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia, Feb 11. doi: 10.1002/glia.23598
  • Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C, Prinz M (2019) Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature 566(7744):388-392
  • Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A (2019) β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration. Nature, Feb 20. doi: 10.1038/s41586-019-0964
  • Töpperwien M, van der Meer F, Stadelmann C, Salditt T (2018) Three-dimensional virtual histology of human cerebellum by X-ray phase-contrast tomography. Proc Natl Acad Sci U S A, Jul 3;115(27):6940-6945
  • Fard MK*, van der Meer F*, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero EF, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz C, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C#, Simons M# (2017) BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med 9(419)pii: eaam7816; *, *co-first, #co-last
  • Lagumersindez-Denis N*, Wrzos C*, Mack M*, Winkler A, van der Meer F, Reinert MC, Hollasch H, Flach A, Bruhl H, Cullen E, Schlumbohm C, Fuchs E, Linington C, Barrantes-Freer A, Metz I, Wegner C, Liebetanz D, Prinz M, Brück W, Stadelmann C#, and Nessler S# (2017) Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol 134(1):15-34. *co-first, #co-corresponding authors
  • Schultz V* van der Meer F*, Wrzos C, Scheidt U, Bahn E, Stadelmann C#, Brück W, Junker A (2017) Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination. Glia, Aug;65(8):1350-1360. doi: 10.1002/glia.23167, * co-first, #corresponding author
  • Bruderer R, Sondermann J, Tsou CC, Barrantes-Freer A, Stadelmann C, Nesvizhskii IA, Schmidt M, Reiter L, Gomez-Varela D (2017) New targeted approaches for the quantification of data-independent acquisition mass spectrometry. Proteomics, May;17(9). doi: 10.1002/pmic.201700021
  • Barrantes-Freer A, Engel AS, Rodríguez-Villagra OA, Winkler A, Bergmann M, Mawrin C, Kuempfel T, Pellkofer H, Metz I, Bleckmann A, Hernández-Durán S, Schippling S, Rushing EJ, Frank S, Glatzel M, Matschke J, Hartmann C, Reifenberger G, Müller W, Schildhaus HU, Brück W, Stadelmann C (2017) Diagnostic Red Flags: Steroid-treated malignant CNS lymphoma mimicking autoimmune inflammatory demyelination. Brain Pathol, Feb 18. doi: 10.1111/bpa.12496
  • Singh S*, Dallenga T*, Winkler A, Roemer S, Maruschak B, Siebert H, Brück W#, Stadelmann C#(2017) Relationship of acute axonal damage, Wallerian degeneration and clinical disability in multiple sclerosis. J Neuroinflammation, Mar 17;14(1):57. doi: 10.1186/s12974-017-0831-8, *co-first, #co-last
  • Wrzos C, Winkler A, Metz I, Kayser DM, Thal DR, Wegner C, Brück W, Nessler S, Bennett JL, Stadelmann C (2014) Early loss of oligodendrocytes in human and experimental neuromyelitis optica lesions. Acta Neuropathol 127: 523-538.
  • Weil MT, Möbius W, Winkler A, Ruhwedel T, Wrzos C, Romanelli E, Bennett JL, Enz L, Goebels N, Nave KA, Kerschensteiner M, Schaeren-Wiemers N, Stadelmann C, Simons M (2016) Loss of myelin basic protein function triggers myelin breakdown in models of neuromyelitis optica. Cell Reports 16(2):314-22
  • Rodriguez EG*, Wegner C*, Kreutzfeldt M, Neid K, Thal DR, Jürgens T, Brück W, Stadelmann C#, Merkler D# (2014) Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination. Acta Neuropathol 128: 231-246; *co-first, #co-last
  • Fledrich R, Stassart RM, Klink A, Rasch LM, Prukop T, Haag L, Czesnik D, Kungl T, Abdelaal TA, Keric N, Stadelmann C, Brück W, Nave KA, Sereda MW (2014) Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A. Nat Med 20:1055-61
  • Boretius S, Escher A, Dallenga T, Wrzos C, Tammer R, Brück W, Nessler S, Frahm J, Stadelmann C (2012) Assessment of lesion pathology in a new animal model ofMS by multiparametric MRI and DTI. Neuroimage 59: 2678-2688
  • Schirmer L, Antel JP, Brück W, Stadelmann C (2011) Axonal loss and neurofilament phosphorylation changes accompany lesion development and clinical progression in multiple sclerosis. Brain Pathol 21: 428-440
  • Schirmer L, Albert M, Buss A, Schulz-Schaeffer WJ, Antel JP, Brück W, Stadelmann C (2009) Substantial early, but non-progressive neuronal loss in multiple sclerosis (MS) spinal cord. Ann Neurol 66: 698-704
  • Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, Glogowska M, Case D, Antel JP, Owens GP, Gilden D, Nessler S, Stadelmann C, Hemmer B (2009). Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 66: 617-629
  • Brüstle A, Heink S, Huber M, Rosenplänter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M (2007) The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 8:958-66
  • Albert M, Antel J, Brück W, Stadelmann C (2007) Extensive cortical remyelination in patients with chronic multiple sclerosis. Brain Pathol 17 (2):129-138
  • Merkler D*, Ernsting T*, Kerschensteiner M, Brück W#, Stadelmann C# (2006) A new focal EAE model of cortical demyelination: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination. Brain 129: 1972-1983, *co-first, #co-last

Arbeitsgruppe Prof. Dr. Martin Weber

2019
  • Garcia-Agudo, L. F., H. Janova, L. E. Sendler, S. Arinrad, A. A. Steixner, I. Hassouna, E. Balmuth, A. Ronnenberg, N. Schopf, F. J. van der Flier, M. Begemann, H. Martens, M. S. Weber, S. Boretius, K. A. Nave and H. Ehrenreich (2019). "Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion." FASEB J 33(7): 8634-8647.
  • Giotaki, I., P. Lange and M. S. Weber (2019). "Modification of CSF findings in multiple sclerosis in the era of rapidly expanding treatment options." Expert Rev Neurother 19(3): 277-283.
  • Greenfield, A. L., R. Dandekar, A. Ramesh, E. L. Eggers, H. Wu, S. Laurent, W. Harkin, N. S. Pierson, M. S. Weber, R. G. Henry, A. Bischof, B. A. Cree, S. L. Hauser, M. R. Wilson and H. C. von Budingen (2019). "Longitudinally persistent cerebrospinal fluid B cells can resist treatment in multiple sclerosis." JCI Insight 4(6): pii: 126599.
  • Hausler, D., S. Torke, E. Peelen, T. Bertsch, M. Djukic, R. Nau, C. Larochelle, S. S. Zamvil, W. Bruck and M. S. Weber (2019). "High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium." Brain 142(9): 2737-2755.
  • Montalban, X., D. L. Arnold, M. S. Weber, I. Staikov, K. Piasecka-Stryczynska, J. Willmer, E. C. Martin, F. Dangond, S. Syed, J. S. Wolinsky and G. Evobrutinib Phase 2 Study (2019). "Placebo-Controlled Trial of an Oral BTK Inhibitor in Multiple Sclerosis." N Engl J Med 380(25): 2406-2417.
  • Traub, J., S. Traffehn, J. Ochs, S. Hausser-Kinzel, S. Stephan, R. Scannevin, W. Bruck, I. Metz and M. S. Weber (2019). "Dimethyl fumarate impairs differentiated B cells and fosters central nervous system integrity in treatment of multiple sclerosis." Brain Pathol 29(5): 640-657.
  • Traub, J. W., H. L. Pellkofer, K. Grondey, I. Seeger, C. Rowold, W. Bruck, L. Husseini, S. Hausser-Kinzel and M. S. Weber (2019). "Natalizumab promotes activation and pro-inflammatory differentiation of peripheral B cells in multiple sclerosis patients." J Neuroinflammation 16(1): 228.
2018
  • Hausler, D., S. Hausser-Kinzel, L. Feldmann, S. Torke, G. Lepennetier, C. C. A. Bernard, S. S. Zamvil, W. Bruck, K. Lehmann-Horn and M. S. Weber (2018). "Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease." Proc Natl Acad Sci U S A 115(39): 9773-9778.
  • Weber, M. S., T. Derfuss and W. Bruck (2018). "Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Central Nervous System Demyelination-A Novel Disease Entity?" JAMA Neurol 75(8): 909-910.
2017
  • Fereidan-Esfahani, M., F. Mahmudi, M. Jahansouz, M. S. Weber and M. Rodriguez (2017). "Biomarkers in radiologically isolated syndrome: The missing piece in the puzzle of treatment indication?" J Neurol Sci 375: 129.
  • Kinzel, S. and M. S. Weber (2017). "The Role of Peripheral CNS-Directed Antibodies in Promoting Inflammatory CNS Demyelination." Brain Sci 7(7).
  • Lehmann-Horn, K., S. Kinzel and M. S. Weber (2017). "Deciphering the Role of B Cells in Multiple Sclerosis-Towards Specific Targeting of Pathogenic Function." Int J Mol Sci 18(10).
2016
  • Bjarnadottir, K., M. Benkhoucha, D. Merkler, M. S. Weber, N. L. Payne, C. C. A. Bernard, N. Molnarfi and P. H. Lalive (2016). "B cell-derived transforming growth factor-beta1 expression limits the induction phase of autoimmune neuroinflammation." Sci Rep 6: 34594.
  • Janova, H., C. Bottcher, I. R. Holtman, T. Regen, D. van Rossum, A. Gotz, A. S. Ernst, C. Fritsche, U. Gertig, N. Saiepour, K. Gronke, C. Wrzos, S. Ribes, S. Rolfes, J. Weinstein, H. Ehrenreich, T. Pukrop, J. Kopatz, C. Stadelmann, G. Salinas-Riester, M. S. Weber, M. Prinz, W. Bruck, B. J. Eggen, H. W. Boddeke, J. Priller and U. K. Hanisch (2016). "CD14 is a key organizer of microglial responses to CNS infection and injury." Glia 64(4): 635-649.
  • Kinzel, S., K. Lehmann-Horn, S. Torke, D. Hausler, A. Winkler, C. Stadelmann, N. Payne, L. Feldmann, A. Saiz, M. Reindl, P. H. Lalive, C. C. Bernard, W. Bruck and M. S. Weber (2016). "Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen." Acta Neuropathol 132(1): 43-58.
  • Romanelli, E., D. Merkler, A. Mezydlo, M. T. Weil, M. S. Weber, I. Nikic, S. Potz, E. Meinl, F. E. Matznick, M. Kreutzfeldt, A. Ghanem, K. K. Conzelmann, I. Metz, W. Bruck, M. Routh, M. Simons, D. Bishop, T. Misgeld and M. Kerschensteiner (2016). "Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model." Nat Commun 7: 13275.
2015
  • Fereidan-Esfahani, M., W. Bruck and M. S. Weber (2015). "Targeting Central Nervous System B Cells in Progression of Multiple Sclerosis: Is Intrathecal Anti-CD20 a Therapeutic Option?" JAMA Neurol 72(12): 1407-1408.
  • Menzfeld, C., M. John, D. van Rossum, T. Regen, J. Scheffel, H. Janova, A. Gotz, S. Ribes, R. Nau, A. Borisch, P. Boutin, K. Neumann, V. Bremes, J. Wienands, H. M. Reichardt, F. Luhder, D. Tischner, V. Waetzig, T. Herdegen, P. Teismann, I. Greig, M. Muller, T. Pukrop, A. Mildner, H. Kettenmann, W. Bruck, M. Prinz, S. Rotshenker, M. S. Weber and U. K. Hanisch (2015). "Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism." Glia 63(6): 1083-1099.
  • Metz, I., S. Traffehn, K. Straßburger-Krogias, K. Keyvani, M. Bergmann, K. Nolte, M. S. Weber, T. Bartsch, R. Gold and W. Brück (2015). "Glial cells express nuclear nrf2 after fumarate treatment for multiple sclerosis and psoriasis." Neurology(R) neuroimmunology & neuroinflammation 2(3): e99.
2014
  • Lehmann-Horn, K., S. Kinzel, L. Feldmann, F. Radelfahr, B. Hemmer, S. Traffehn, C. C. Bernard, C. Stadelmann, W. Bruck and M. S. Weber (2014). "Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity." Ann Clin Transl Neurol 1(7): 490-496.
  • Shetty, A., S. G. Gupta, M. Varrin-Doyer, M. S. Weber, T. Prod'homme, N. Molnarfi, N. Ji, P. A. Nelson, J. C. Patarroyo, U. Schulze-Topphoff, S. E. Fogal, T. Forsthuber, R. A. Sobel, C. C. Bernard, A. J. Slavin and S. S. Zamvil (2014). "Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE." Neurol Neuroimmunol Neuroinflamm 1(2): e22.
  • Varrin-Doyer, M., A. Shetty, C. M. Spencer, U. Schulze-Topphoff, M. S. Weber, C. C. Bernard, T. Forsthuber, B. A. Cree, A. J. Slavin and S. S. Zamvil (2014). "MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS." Neurol Neuroimmunol Neuroinflamm 1(2): e20.
  • Weber, M. S., T. Prod'homme, S. Youssef, S. E. Dunn, L. Steinman and S. S. Zamvil (2014). "Neither T-helper type 2 nor Foxp3+ regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity." J Neuroinflammation 11: 29.
2013
  • Bruck, W., R. Gold, B. T. Lund, C. Oreja-Guevara, A. Prat, C. M. Spencer, L. Steinman, M. Tintore, T. L. Vollmer, M. S. Weber, L. P. Weiner, T. Ziemssen and S. S. Zamvil (2013). "Therapeutic decisions in multiple sclerosis: moving beyond efficacy." JAMA Neurol 70(10): 1315-1324.
  • Cravens, P. D., B. C. Kieseier, R. Hussain, E. Herndon, B. Arellano, L. H. Ben, B. C. Timmons, C. Castro-Rojas, H. P. Hartung, B. Hemmer, M. S. Weber, S. S. Zamvil and O. Stuve (2013). "The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis." J Neuroinflammation 10: 67.
  • Hertzenberg, D., K. Lehmann-Horn, S. Kinzel, V. Husterer, P. D. Cravens, B. C. Kieseier, B. Hemmer, W. Bruck, S. S. Zamvil, O. Stuve and M. S. Weber (2013). "Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity." Eur J Immunol 43(8): 2078-2088.
  • Molnarfi, N., U. Schulze-Topphoff, M. S. Weber, J. C. Patarroyo, T. Prod'homme, M. Varrin-Doyer, A. Shetty, C. Linington, A. J. Slavin, J. Hidalgo, D. E. Jenne, H. Wekerle, R. A. Sobel, C. C. Bernard, M. J. Shlomchik and S. S. Zamvil (2013). "MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies." J Exp Med 210(13): 2921-2937.

Arbeitsgruppe Prof. Imke Metz

Ausgewählte aktuelle Publikationen:

  • Hoepner R, Bagnoud M, Pistor M, Salmen A, Briner M, Synn H, Schrewe L, Guse K, Ahmadi F, Demir S, Laverick L, Gresle M, Worley P, Reichardt HM, Butzkueven H, Gold R, Metz I, Lühder F, Chan A. Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis. Acta Neuropathol. 2019 Apr 27. doi: 10.1007/s00401-019-02018-8. 
  • Traub J, Traffehn S, Ochs J, Häusser-Kinzel S, Stephan S, Scannevin R, Brück W, Metz I*, Weber MS*. Dimethyl fumarate impairs differentiated B cells and fosters central nervous system integrity in treatment of multiple sclerosis. Brain Pathol. 2019 Jan 31. doi: 10.1111/bpa.12711. *Co-last authors
  • Stork L, Brück W, von Gottberg P, Pulkowski U, Kirsten F, Glatzel M, Rauer S, Scheibe F, Radbruch H, Hammer E, Stürner KH, Kaulen B, Heesen C, Hoffmann F, Brock S, Pawlitzki M, Bopp T, Metz I. Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis. Mult Scler. 2019 Jan 18:1352458518819098. doi: 10.1177/1352458518819098. PMID: 3065742
  • Scheibe F, Metz I, Radbruch H, Siebert E, Wolf S, Köhnlein M, Harms L, Meisel A. Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy in MS. Neurol Neuroimmunol Neuroinflamm. 2018 Jul 10;5(5):e479. doi: 10.1212/NXI.0000000000000479. eCollection 2018 Sep.PMID:30027105 
  • Rauer S, Stork L, Urbach H, Stathi A, Marx A, Süß P, Prinz M, Brück W, Metz I. Drug reaction with eosinophilia and systemic symptoms after daclizumab therapy. Neurology. 2018 Jul 24;91(4):e359-e363. doi: 10.1212/WNL.0000000000005854. Epub 2018 Jun 22. PMID:29934423. 
  • Stork L, Ellenberger D, Beißbarth T, Friede T, Lucchinetti CF, Brück W, Metz I. Differences in the Reponses to Apheresis Therapy of Patients With 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis. JAMA Neurol. 2018 Apr 1;75(4):428-435. doi: 10.1001/jamaneurol.2017.4842. PMID: 29404583
  • Weber MS, Derfuss T, Metz I, Brück W. Defining distinct features of anti-MOG antibody associated central nervous system demyelination. Ther Adv Neurol Disord. 2018 Mar 29;11:1756286418762083. doi: 10.1177/1756286418762083. eCollection 2018. PMID: 29623106
  • Planas R, Metz I, Martin R, Sospedra M. Detailed Characterization of T Cell Receptor Repertoires in Multiple Sclerosis Brain Lesions. Front Immunol. 2018 Mar 19;9:509. doi: 10.3389/fimmu.2018.00509. eCollection 2018. PMID: 29616027
  • Popescu BF, Frischer JM, Webb SM, Tham M, Adiele RC, Robinson CA, Fitz-Gibbon PD, Weigand SD, Metz I, Nehzati S, George GN, Pickering IJ, Brück W, Hametner S, Lassmann H, Parisi JE, Yong G, Lucchinetti CF. Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions. Acta Neuropathol. 2017 Jul;134(1):45-64. doi: 10.1007/s00401-017-1696-8. Epub 2017 Mar 22. PMID: 28332093
  • Metz I, Rieckmann P, Kallmann BA, Brück W. Disseminated necrotizing leukoencephalopathy eight month after alemtuzumab treatment for multiple sclerosis. Acta Neuropathol Commun. 2016 Aug 8;4(1):81. doi: 10.1186/s40478-016-0352-1. No abstract available. PMID: 27503238
  • Metz I, Beißbarth T, Ellenberger D, Pache F, Stork L, Ringelstein M, Aktas O, Jarius S, Wildemann B, Dihazi H, Friede T, Brück W, Ruprecht K, Paul F. Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Feb 2;3(2):e204. doi: 10.1212/NXI.0000000000000204. eCollection 2016 Apr. PMID: 26894206
  • Jarius S*, Metz I*, König FB, Ruprecht K, Reindl M, Paul F, Brück W, Wildemann B. Screening for MOG-IgG and 27 other anti-Glial and anti-neuronal autoantibodies in `patterns II multiple sclerosis´ and brain biopsy findings in a MOG-IgG-positive case. Mult Scler. 2016 Feb 11. pii: 1352458515622986. [Epub ahead of print]. PMID: 26869529, *Co first-authors 

Ausgewählte ältere Publikationen:

  • Häusler D, Nessler S, Kruse N, Brück W, Metz I. Natalizumab analogon therapy is effective in a B cell-dependent multiple sclerosis model. Neuropathol Appl Neurobiol. 2015 Oct;41(6):814-31. doi: 10.1111/nan.12220. Epub 2015 May 2.
  • Stork L, Brück W, Bar-Or A, Metz I. High CCR5 expression in natalizumab-associated progressive multifocal leukoencephalopathy immune reconstitution inflammatory syndrome supports treatment with the CCR5 inhibitor maraviroc. Acta Neuropathol. 2015 Mar;129(3):467-8. doi: 10.1007/s00401-015-1391-6.
  • Metz I, Weigand SD, Popescu BF, Frischer JM, Parisi JE, Guo Y, Lassmann H, Brück W, Lucchinetti CF. Pathologic heterogeneity persists in early active multiple sclerosis lesions. Ann Neurol. 2014 May;75(5):728-38. doi: 10.1002/ana.24163. Epub 2014 May 13.
  • Giacomini PS, Rozenberg A, Metz I, Araujo D, Arbour N, Bar-Or A; Maraviroc in Multiple Sclerosis–Associated PML–IRIS (MIMSAPI) Group. Maraviroc and JC virus-associated immune reconstitution inflammatory syndrome. N Engl J Med. 2014 Jan 30;370(5):486-8.
  • Brück W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, Metz, I; Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate.  Ann Neurol. 2012 Sep;72(3):385-94. 
  • Metz I, Radue E-W, Oterino A, Kümpfel T, Wiendl H, Schippling S, Kuhle J, Sahraian MA, Gray F, Jakl V, Häusler D, Brück W; Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy. Acta Neuropathol (2012) 123:235–245
  • Dziedzic T*, Metz I*, Dallenga T*, König FB, Müller S, Stadelmann C, Brück W; Wallerian degeneration: a major component of early axonal pathology in multiple sclerosis. Brain Pathol. 2010 Sep;20(5):976-85. * Co-first authors.
  • Metz I, Lucchinetti CF, Openshaw H, Garcia-Merino A, Lassmann H, Freedman MS, Atkins HL, Azzarelli B, Kolar OJ, Brück W.; Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis. Brain. 2007 May;130(Pt 5):1254-62.

Arbeitsgruppe Dr. Stefan Nessler

Ausgewählte aktuelle Publikationen:

  • Ott M*, Avendaño-Guzmán E*, Ullrich E, Dreyer C, Strauss J, Harden M, Schön M, Schön MP, Bernhardt G, Stadelmann C, Wegner C#, Brück W#, Nessler S# (2019). Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity. J Neuroinflammation 16 (1): 49. doi: 10.1186/s12974-019-1437-0. *shared first authorship; #shared senior authorship
  • Bergner CG, van der Meer F, Winkler W, Wrzos C, Türkmen M, Valizada E, Fitzner D, Hametner S, Hartmann A, Pfeifenbring S, Stoltenburg-Didinger G, Brück W, Nessler S, Stadelmann C (2019) Microglia damage precedes major myelin destruction in X-linked adrenoleukodystrophy and metachromatic leukodystrophy. Glia, Feb 11. doi: 10.1002/glia.23598
  • Masuda T, Sankowski R, Staszewski O, Böttcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grün D, Priller J, Stadelmann C, Prinz M (2019) Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature 566(7744):388-392
  • Lüders KA, Nessler S, Kusch K, Patzig J, Jung RB, Möbius W, Nave KA, Werner HB (2019). Continued maintenance of high proteolipid protein level in adult CNS myelin is required to preserve the integrity of myelin and axons. Glia 67 (4): 634-649.
  • Stojic A, Bojcevski J, Williams SK, Bas-Orth C, Nessler S, Linington C, Diem R, Fairless R (2019). Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. Glia 67 (3): 512-524
  • Lagumersindez-Denis N*, Wrzos C*, Mack M*, Winkler A, van der Meer F, Reinert MC, Hollasch H, Flach A, Bruhl H, Cullen E, Schlumbohm C, Fuchs E, Linington C, Barrantes-Freer A, Metz I, Wegner C, Liebetanz D, Prinz M, Brück W, Stadelmann C, and Nessler S (2017) Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol 134(1):15-34. *co-first
  • Ribes S, Nessler S, Heide EC, Malzahn D, Perske C, Brück W, Nau R (2017). The Early Adaptive Immune Response in the Pathophysiological Process of Pneumococcal Meningitis. J Infect Dis. 215 (1): 150-158.

Ausgewählte ältere Publikationen:

  • Hu W*, Nessler S*, Hemmer B, Eagar TN, Kane LP, Leliveld SR, Müller-Schiffmann A, Gocke AR, Lovett-Racke A, Ben LH, Hussain RZ, Breil A, Elliott JL, Puttaparthi K, Cravens PD, Singh MP, Petsch B, Stitz L, Racke MK, Korth C, Stüve O (2010). Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling. Brain 133: 375-88. (*co-first)
  • Bennett JL, Lam C, Kalluri SR, Saikali P, Bautista K, Dupree C, Glogowska M, Case D, Antel JP, Owens GP, Gilden D, Nessler S, Stadelmann C, Hemmer B (2009). Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica. Ann Neurol 66: 617-629
  • Nessler S*, Boretius S*, Stadelmann C*, Bittner A, Merkler D, Hartung HP, Michaelis T, Brück W, Frahm J, Sommer N, Hemmer B (2007). Early MRI changes in a mouse model of multiple sclerosis are predictive of severe inflammatory tissue damage. Brain 130 (Pt 8):2186-98. (*co-first
  • Zhou D, Srivastava R, Nessler S, Grummel V, Sommer N, Brück W, Hartung HP, Stadelmann C, Hemmer B (2006). Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis. PNAS 103 (50): 19057-62.
  • Stüve O, Youssef S, Weber MS, Nessler S, von Büdingen HC, Hemmer B, Prod'homme T, Sobel RA, Steinman L, Zamvil SS (2006). Immunomodulatory synergy by combination of atorvastatin and glatiramer acetate in treatment of CNS autoimmunity. JCI  116 (4): 1037-44.
  • Cepok S, Zhou D, Srivastava R, Nessler S, Stei S, Büssow K, Sommer N, Hemmer B (2005). Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis. JCI 115 (5): 1352-60

Arbeitsgruppe Prof. Ruben Fernandez-Busnadiego

  •  J. Collado, M. Kalemanov, A. Martínez-Sánchez, F. Campelo, W. Baumeister, C.J. Stefan and R. Fernández-Busnadiego. Tricalbin‐mediated contact sites control ER curvature to maintain plasma membrane integrity. Dev Cell (2019) 51(4):476-487.
  • Q. Guo, B. Huang, J. Cheng, M. Seefelder, T. Engler, G. Pfeifer, P. Oeckl, M. Otto, F. Moser, M. Maurer, A. Pautsch, W. Baumeister, R. Fernández-Busnadiego* and S. Kochanek. The cryo-EM structure of huntingtin. Nature (2018), 555(7694): 117-120. *Co-corresponding author. PubMed. Recommended by F1000.
  • Q. Guo, C. Lehmer, A. Martínez-Sánchez, T. Rudack, F. Beck, H. Hartmann, M.S. Hipp, F.U. Hartl, D. Edbauer and W. Baumeister and R. Fernández-Busnadiego. In situ structure of neuronal C9orf72 poly-GA aggregates reveals proteasome recruitment. Cell (2018), 172(4): 696-705. PubMed. News and Views in Nature. Recommended by F1000.
  • F.J. Bäuerlein, I. Saha, A. Mishra, M. Kalemanov, A. Martinez-Sanchez, R. Klein, I. Dudanova, M.S. Hipp, F.U. Hartl, W. Baumeister and R. Fernández-Busnadiego. In situ architecture and cellular interactions of polyQ inclusions. Cell (2017), 171(1): 179-187. PubMed. Journal commentary. Recommended by F1000.
  • R. Fernández-Busnadiego, Y. Saheki and P. De Camilli. Three dimensional architecture of E-Syt-mediated endoplasmic reticulum-plasma membrane contact sites.PNAS (2015), 112 (16) E2004-13. PubMed. Journal commentary.
  • R. Fernández-Busnadiego, S. Asano, A.M. Oprisoreanu, E. Sakata, M. Doengi, Z. Kochovski, M. Zürner, V. Stein, S. Schoch, W. Baumeister and V. Lučić. Cryo-electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering. J Cell Biol (2013), 201 725-740. PubMed.

Arbeitsgruppe Prof. Nau

Ausgewählte Publikationen
  • Ribes S, Meister T, Ott M, Redlich S, Janova H, Hanisch UK, Nessler S, Nau R. Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection. J Neuroinflammation 2014.
  • Tauber SC, Harms K, Falkenburger B, Weis J, Sellhaus B, Nau R, Schulz JB, Reich A. Modulation of hippocampal neuroplasticity by Fas/CD95 regulatory protein 2 (Faim2) in the course of bacterial meningitis. J Neuropathol Exp Neurol. 2014;73(1):2-13.
  • Nau R, Djukic M, Spreer A, Eiffert H. Bacterial meningitis: new therapeutic approaches. Expert Rev Anti Infect Ther. 2013;11(10):1079-95.
  • Ribes S, Riegelmann J, Redlich S, Maestro B, de Waal B, Meijer EW, Sanz JM, Nau R. Multivalent choline dendrimers increase phagocytosis of Streptococcus pneumoniae R6 by microglial cells. Chemotherapy. 2013;59(2):138-42.
  • Wippel C, Maurer J, Förtsch C, Hupp S, Bohl A, Ma J, Mitchell TJ, Bunkowski S, Brück W, Nau R, Iliev AI. Bacterial cytolysin during meningitis disrupts the regulation of glutamate in the brain, leading to synaptic damage. PLoS Pathog. 2013;9(6):e1003380.
  • Redlich S, Ribes S, Schütze S, Eiffert H, Nau R. Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells. J Neuroinflammation 2013;10:71.
  • Tauber SC, Eiffert H, Kellner S, Lugert R, Bunkowski S, Schütze S, Perske C, Brück W, Nau R. Fungal encephalitis in human autopsy cases is associated with extensive neuronal damage but only minimal repair. Neuropathol Appl Neurobiol. 2013 Mar 21.
  • Ribes S, Regen T, Meister T, Tauber SC, Schütze S, Mildner A, Mack M, Hanisch UK, Nau R. Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes. Infect Immun. 2013;81(5):1810-9.
  • Focke NK, Kallenberg K, Mohr A, Djukic M, Nau R, Schmidt H. Distributed, limbic gray matter atrophy in patients after bacterial meningitis. AJNR Am J Neuroradiol. 2013;34(6):1164-7
  • Disselberg C, Ribes S, Michel U, Redlich S, Brück W, Nau R, Schütze S. Follistatin does not influence the course of Escherichia coli K1 sepsis in a mouse model. Shock. 2012;38(6):615-9.
  • Djukic M, Schulz D, Schmidt H, Lange P, Nau R. Cerebrospinal fluid findings in geriatric patients from 2008 to 2011. Z Gerontol Geriatr. 2013;46(4):353-7.
  • Ribes S, Adam N, Schütze S, Regen T, Redlich S, Janova H, Borisch A, Hanisch UK, Nau R. The nucleotide-binding oligomerization domain-containing-2 ligand muramyl dipeptide enhances phagocytosis and intracellular killing of Escherichia coli K1 by Toll-like receptor agonists in microglial cells. J Neuroimmunol. 2012;252(1-2):16-23.
  • Liebetanz D, Gerber J, Schiffner C, Schütze S, Klinker F, Jarry H, Nau R, Tauber SC. Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis. J Neuroinflammation. 2012;9:168.
  • Gerber J, Redlich S, Ribes S, Tauber SC, Schmidt H, Nau R. Intrathecal treatment with the anti-phosphorylcholine monoclonal antibody TEPC-15 decreases neuronal damage in experimental pneumococcal meningitis. Chemotherapy. 2012;58(3):212-6.
  • Schütze S, Loleit T, Zeretzke M, Bunkowski S, Brück W, Ribes S, Nau R. Additive microglia-mediated neuronal injury caused by amyloid-? and bacterial TLR agonists in murine neuron-microglia co-cultures quantified by an automated image analysis using cognition network technology. J Alzheimers Dis. 2012;31(3):651-7.
  • Redlich S, Ribes S, Schütze S, Czesnik D, Nau R. Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells. J Neuroimmunol. 2012;244(1-2):32-4.
  • Djukic M, Munz M, Sörgel F, Holzgrabe U, Eiffert H, Nau R. Overton's rule helps to estimate the penetration of anti-infectives into patients' cerebrospinal fluid. Antimicrob Agents Chemother. 2012;56(2):979-88.
  • Fronek K, Lange P, Spreer A, Eiffert H, Nau R. Bacterial contamination and the transport vial material affect cerebrospinal fluid concentrations of ?-Amyloid and Tau protein as determined by enzyme immunoassay. Dement Geriatr Cogn Disord. 2011;32(2):126-34.
  • Djukic M, Schmidt-Samoa C, Lange P, Spreer A, Neubieser K, Eiffert H, Nau R, Schmidt H. Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis. J Neurol. 2012;259(4):630-6.
  • Tauber SC, Ribes S, Ebert S, Heinz T, Fingerle V, Bunkowski S, Kugelstadt D, Spreer A, Jahn O, Eiffert H, Nau R. Long-term intrathecal infusion of outer surface protein C from Borrelia burgdorferi causes axonal damage. J Neuropathol Exp Neurol. 2011;70(9):748-57.
  • Jung K, Goerdt C, Lange P, Blocher J, Djukic M, Gerber J, Spreer A, Nau R, Otto M, Schmidt H. The use of S100B and Tau protein concentrations in the cerebrospinal fluid for the differential diagnosis of bacterial meningitis: a retrospective analysis. Eur Neurol. 2011;66(3):128-32.
  • Tauber SC, Bunkowski S, Brück W, Nau R. Septic metastatic encephalitis: coexistence of brain damage and repair. Neuropathol Appl Neurobiol. 2011;37(7):768-76.
  • Djukic M, Schmidt-Samoa C, Nau R, von Steinbüchel N, Eiffert H, Schmidt H. The diagnostic spectrum in patients with suspected chronic Lyme neuroborreliosis--the experience from one year of a university hospital's Lyme neuroborreliosis outpatients clinic. Eur J Neurol. 2011;18(4):547-55.
  • Nau R, Sörgel F, Eiffert H. Penetration of drugs through the blood-cerebrospinal fluid/blood-brain barrier for treatment of central nervous system infections. Clin Microbiol Rev. 2010;23(4):858-83.
  • Ebert S, Nau R, Michel U. Role of activin in bacterial infections: a potential target for immunointervention? Immunotherapy. 2010;2(5):673-84.
  • Ribes S, Adam N, Ebert S, Regen T, Bunkowski S, Hanisch UK, Nau R. The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells. Neurosci Lett. 2010;482(1):17-20.
  • Jensch I, Gámez G, Rothe M, Ebert S, Fulde M, Somplatzki D, Bergmann S, Petruschka L, Rohde M, Nau R, Hammerschmidt S. PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections. Mol Microbiol. 2010;77(1):22-43.
  • Gerber J, Nau R. Mechanisms of injury in bacterial meningitis. Curr Opin Neurol. 2010;23(3):312-8.
  • Schmidt H, Gerber J, Stuertz K, Djukic M, Bunkowski S, Fischer FR, Otto M, Nau R. S100B in the cerebrospinal fluid--a marker for glial damage in the rabbit model of pneumococcal meningitis. Neurosci Lett. 2010;475(2):104-7.
  • Ribes S, Ebert S, Regen T, Agarwal A, Tauber SC, Czesnik D, Spreer A, Bunkowski S, Eiffert H, Hanisch UK, Hammerschmidt S, Nau R. Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia. Infect Immun. 2010;78(2):865-71
  • Tauber SC, Ebert S, Weishaupt JH, Reich A, Nau R, Gerber J. Stimulation of Toll-like receptor 9 by chronic intraventricular unmethylated cytosine-guanine DNA infusion causes neuroinflammation and impaired spatial memory. J Neuropathol Exp Neurol. 2009;68(10):1116-24.
  • Ebert S, Goos M, Rollwagen L, Baake D, Zech WD, Esselmann H, Wiltfang J, Mollenhauer B, Schliebs R, Gerber J, Nau R. Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseases. J Neurosci Res. 2010;88(5):1124-36.
  • Gerber J, Tauber SC, Armbrecht I, Schmidt H, Brück W, Nau R. Increased neuronal proliferation in human bacterial meningitis. Neurology. 2009;73(13):1026-32.
  • Ribes S, Ebert S, Regen T, Czesnik D, Scheffel J, Zeug A, Bunkowski S, Eiffert H, Hanisch UK, Hammerschmidt S, Nau R. Fibronectin stimulates Escherichia coli phagocytosis by microglial cells. Glia. 2010;58(3):367-76.

Arbeitsgruppe Prof. Dr. Wolfgang Brück

  • Kramann N, Menken L, Pförtner R, Schmid SN, Stadelmann C, Wegner C, Brück W. Glial fibrillary acidic protein expression alters astrocytic chemokine release and protects mice from cuprizone-induced demyelination. Glia. 2019 Feb 23. doi: 10.1002/glia.23605. [Epub ahead of print]
  • Stork L, Ellenberger D, Beißbarth T, Friede T, Lucchinetti CF, Brück W, Metz I. Differences in the Reponses to Apheresis Therapy of Patients with 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis. JAMA Neurol, 75: 428-435, 2018
  • Jürgens T, Jafari M, Kreutzfeldt M, Bahn E, Brück W, Kerschensteiner M, Merkler D (2016) Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. Brain 139, 39-46
  • Pfeifenbring S, Nessler S, Wegner C, Stadelmann C, Brück W (2015) Remyelination After Cuprizone-Induced Demyelination Is Accelerated in Juvenile Mice. J Neuropathol Exp Neurol 74, 756-66
  • Pfeifenbring S, Bunyan RF, Metz I, Röver C, Huppke P, Gärtner J, Lucchinetti CF, Brück W (2015) Extensive acute axonal damage in pediatric multiple sclerosis lesions. Ann Neurol 77, 655-667
  • Metz I, Weigand SD, Popescu BF, Frischer JM, Parisi JE, Guo Y, Lassmann H, Brück W*, Lucchinetti CF* (2014) Pathologic heterogeneity persists in early active multiple sclerosis lesions. Ann Neurol 75, 728-738
  • Singh S, Metz I, Amor S, van der Valk P, Stadelmann C, Brück W (2013) Microglial nodules in early multiple sclerosis white matter are associated with degenerating axons. Acta Neuropathol 125, 595-608
  • Brück W, Pförtner R, Pham T, Zhang J, Hayardeny L, Piryatinsky V, Hanisch UK, Regen T, van Rossum D, Brakelmann L, Hagemeier K, Kuhlmann T, Stadelmann C, John GR, Kramann N, Wegner C (2012) Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination. Acta Neuropathol 124, 411-424
  • Brück W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, Metz I (2012) Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate. Ann Neurol 72, 385-394
  • Metz I, Radue EW, Oterino A, Kümpfel T, Wiendl H, Schippling S, Kuhle J, Sahraian MA, Gray F, Jakl V, Häusler D, Brück W (2012) Pathology of immune reconstitution inflammatory syndrome in multiple sclerosis with natalizumab-associated progressive multifocal leukoencephalopathy. Acta Neuropathol 123, 235-245

Das könnte Sie auch interessieren

Folgen Sie uns